Ligue 1 leaders Monaco moved three points clear with victory at Guingamp.
Monaco defender Kamil Glik stabbed in the opener from Thomas Lemar's first-half free-kick, helped on by Guingamp winger Jimmy Briand's poor clearance.
Falcao saw a bicycle kick diverted just over the bar, before 18-year-old striker Kylian Mbappe was fouled in the box by keeper Karl-Johan Johnsson.
Fabinho's chipped penalty put Monaco 2-0 up, before Etienne Didot fired home a late consolation from outside the box.
Second-placed Nice had moved level on points with Leonardo Jardim's side with a 2-1 home victory over Montpellier on Friday.
Defending champions Paris St-Germain, in third, are now six points behind Monaco but can narrow the gap when they play at Marseille on Sunday (20:00 GMT).
Monaco were beaten 5-3 by Manchester City in their Champions League last-16 first leg on Tuesday. They host City for the second leg on Wednesday, 15 March.
Elsewhere, Bordeaux moved up to fifth with a 3-2 win away to a Lille side that had two players sent off in the final 10 minutes.
Bottom side Lorient lost 1-0 at Rennes, who move up to eighth, Angers beat Bastia 3-0, and Nancy and Toulouse played out a goalless draw.
